Transplantation of dental tissue-derived mesenchymal stem cells ameliorates nephritis in lupus mice | Zendy

Xiaojun Tang | Zendy; Wenchao Li | Zendy; Xin Wen | Zendy; Zhuoya Zhang | Zendy; Weiwei Chen | Zendy; Genhong Yao | Zendy; Hongwei Chen | Zendy; Dandan Wang | Zendy; Songtao Shi | Zendy; Lingyun Sun | Zendy

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Transplantation of dental tissue-derived mesenchymal stem cells ameliorates nephritis in lupus mice

Author(s) -

Xiaojun Tang,

Wenchao Li,

Xin Wen,

Zhuoya Zhang,

Weiwei Chen,

Genhong Yao,

Hongwei Chen,

Dandan Wang,

Songtao Shi,

Lingyun Sun

Publication year - 2019

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2019.02.41

Subject(s) - mesenchymal stem cell , periodontal ligament stem cells , transplantation , foxp3 , lupus nephritis , medicine , immunology , stem cell , dental pulp stem cells , andrology , pathology , chemistry , biology , alkaline phosphatase , microbiology and biotechnology , immune system , biochemistry , disease , enzyme

Our results show that both DPSCs and PDLSCs can alleviate the disease symptoms of lupus-prone B6/lpr mice. DPSCs are also effective in reducing kidney glomerular lesion and perivascular inflammation infiltration as well as UC-MSCs, suggesting that DPSCs might be another choice for SLE treatment.

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