Basal insulin reductions in anticipation of multiple exercise sessions in people with type 1 diabetes—a clinical perspective | Zendy

Olivia McCarthy | Zendy; Steve Baín | Zendy; Rachel Deere | Zendy

Open Access

Basal insulin reductions in anticipation of multiple exercise sessions in people with type 1 diabetes—a clinical perspective

Author(s) -

Olivia McCarthy,

Steve Baín,

Rachel Deere

Publication year - 2018

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2018.11.63

Subject(s) - endocrinology , pancreas , medicine , enteroendocrine cell , glucose homeostasis , amylin , hormone , islet , insulin , basal (medicine) , pancreatic polypeptide , endocrine system , type 2 diabetes , pancreatic islets , secretion , diabetes mellitus , biology , delta cell , beta cell , insulin resistance , glucagon

The islets of Langerhans are regions of the human pancreas that contain endocrine (hormone-producing) cells, constituting 1% to 2% of pancreas volume. There are four main types of endocrine cells within the islets of Langerhans: alpha (α) cells, beta (β) cells, delta (δ) cells and to a lesser degree the pancreatic polypeptide (PP) cells. Of these populations, the β-cells account for between 65–80% of the pancreatic islets, and whilst predominately responsible for the secretion of the hormone insulin, they also co-secrete C-peptide and amylin. Collectively, the cells in the islets of Langerhans are pivotal in glycaemic regulation and homeostasis.

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