A pathogenic hierarchy for synovial fibroblasts in rheumatoid arthritis | Zendy

Mohammed H. Abuwarwar | Zendy; Konstantin Knoblich | Zendy; Anne L. Fletcher | Zendy

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A pathogenic hierarchy for synovial fibroblasts in rheumatoid arthritis

Author(s) -

Mohammed H. Abuwarwar,

Konstantin Knoblich,

Anne L. Fletcher

Publication year - 2018

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2018.10.49

Subject(s) - rheumatoid arthritis , inflammation , medicine , cartilage , immunology , chemokine , population , arthritis , proinflammatory cytokine , bone erosion , anatomy , environmental health

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects 0.5–1% of the world’s population (1). It is characterized by inflammation and progressive destruction of joints (1). Synovial fibroblasts play important roles in initiating and driving RA by secreting inflammatory cytokines and chemokines, degrading cartilage, and stimulating osteoclasts that lead to bone erosion (2).

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