Efficacy characteristics of different therapeutic modalities for locally advanced prostate cancer: a Bayesian network meta-analysis of randomized controlled trials | Zendy

Jianxin Xue | Zendy; Yi Wang | Zendy; Yuxiao Zheng | Zendy; Jianzhong Zhang | Zendy; Feng Qi | Zendy; Hong Cheng | Zendy; Shuhui Si | Zendy; Ran Li | Zendy; Xiao Li | Zendy; Zhiqiang Qin | Zendy; Bin Yu | Zendy; Qing Zou | Zendy

Open Access

Efficacy characteristics of different therapeutic modalities for locally advanced prostate cancer: a Bayesian network meta-analysis of randomized controlled trials

Author(s) -

Jianxin Xue,

Yi Wang,

Yuxiao Zheng,

Jianzhong Zhang,

Feng Qi,

Hong Cheng,

Shuhui Si,

Ran Li,

Xiao Li,

Zhiqiang Qin,

Bin Yu,

Qing Zou

Publication year - 2018

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2018.08.38

Subject(s) - medicine , prostate cancer , oncology , androgen deprivation therapy , hazard ratio , meta analysis , orchiectomy , randomized controlled trial , therapeutic effect , confidence interval , cancer

All in all, our results indicated that RT + LTADT or RT + orchiectomy was among the best two therapeutic regimens in the prognostic aspects of the patients with LAPCa. Furthermore, in consideration of reducing invasive treatment of eligible patients, RT + LTADT could yield better survival benefit of LAPCa patients, compared with others. In addition, the results of our analysis might provide a reference in the clinical selection. Larger sample sizes of strictly designed randomised controlled trials (RCTs) were wanted to validate our findings.

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