Open AccessThe relationship between estrogen-induced phenotypic transformation and proliferation of vascular smooth muscle and hypertensive intracerebral hemorrhage
Author(s) -
Xiaohui Xia,
Changlong Zhou,
Xueg He,
Chang Liu,
Guanyu Wang,
Xiaochuan Sun
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm-20-4567
Subject(s) - vascular smooth muscle , estrogen receptor , endocrinology , estrogen , medicine , gper , apoptosis , tamoxifen , myocardin , angiotensin ii , cancer research , chemistry , receptor , biology , gene expression , gene , serum response factor , smooth muscle , cancer , biochemistry , breast cancer
Estrogen suppresses apoptosis by inhibiting the proliferation of human VSMCs and preventing it from changing from contractile to synthetic. Estrogen can further prevents vascular damage and regulate peripheral inflammatory reaction, thereby producing a protective effect on cardiovascular and cerebrovascular.
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