Open AccessLigustilide modulates oxidative stress, apoptosis, and immunity to avoid pathological damages in bleomycin induced pulmonary fibrosis rats via inactivating TLR4/MyD88/NF-KB P65
Author(s) -
Shu Luo,
Junzuo Gong,
XiaoPing Cao,
Shiping Liu
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm-20-4233
Subject(s) - oxidative stress , bleomycin , fibrosis , pulmonary fibrosis , chemistry , nitric oxide synthase , glutathione peroxidase , superoxide dismutase , endocrinology , medicine , nitric oxide , chemotherapy
LIG improved bleomycin-induced PF with improved ventilation, reduced fibroblast, reduced oxidative stress and apoptosis, and rebalanced Th1/Th2 immunity, through TLR4/MyD88/NF-κB P65 signaling.
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