Open AccessThe combination of forskolin and VPA increases gene expression efficiency to the hypoxia/neuron-specific system
Author(s) -
Zhimin Pan,
Jinsoo Oh,
Lu Huang,
Zhaoxun Zeng,
Pingguo Duan,
Zhiyun Li,
Yeomin Yun,
Janghwan Kim,
Yoon Ha,
Kai Cao
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm-20-3871
Subject(s) - sox2 , genetic enhancement , neun , reprogramming , nestin , induced pluripotent stem cell , neural stem cell , histone deacetylase , cancer research , stem cell , hypoxia (environmental) , gene expression , microbiology and biotechnology , biology , chemistry , gene , embryonic stem cell , histone , immunology , biochemistry , immunohistochemistry , oxygen , organic chemistry
This experiment demonstrated that HNIS-hiNSCs combined with GSK3 and HDAC inhibitors may present another promising strategy in the treatment of SCI.
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