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Department of Radiation Oncology, Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, USA Correspondence to: Michael Mix, MD. Assistant Professor, Department of Radiation Oncology, Upstate Cancer Center, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA. Email: mixm@upstate.edu. Comment on: Moreno AC, Fellman B, Hobbs BP, et al. Biologically Effective Dose in Stereotactic Body Radiotherapy and Survival for Patients With Early-Stage NSCLC. J Thorac Oncol 2020;15:101-9.

A biologically effective dose threshold for stereotactic body radiation therapy—can we put the issue to BED?