Open AccessHigh-dose vitamin C alleviates pancreatic injury via the NRF2/NQO1/HO-1 pathway in a rat model of severe acute pancreatitis
Author(s) -
Lili Xu,
Bing Zhao,
Silei Sun,
Sifei Yu,
Yuming Wang,
Ran Ji,
Zhitao Yang,
Li Ma,
Yi Yao,
Ying Chen,
Huiqiu Sheng,
Erzhen Chen,
Enqiang Mao
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm-19-4552
Subject(s) - oxidative stress , in vivo , tunel assay , apoptosis , acute pancreatitis , chemistry , pharmacology , vitamin c , gene knockdown , pancreatitis , antioxidant , in vitro , vitamin e , medicine , biology , biochemistry , microbiology and biotechnology
The present study suggests that high-dose of VC ameliorate pancreatic injury of SAP via the NRF2/NQO1/HO-1 pathway to inhibit oxidative stress.
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