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Transient receptor potential canonical 5 channel is involved in the cardiac damage related to obstructive sleep apnea-hypopnea syndrome in rats
Author(s) -
Wen Wen,
Qiaoling Yao,
Yulan Chen,
Zhiqiang Li,
Bumairemu Maitikuerban,
Yu Zhang,
Junshi Zhang,
Zhulepiya Simayi,
Xinjuan Xu,
Xiangyang Zhang
Publication year - 2020
Publication title -
annals of palliative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 19
eISSN - 2224-5839
pISSN - 2224-5820
DOI - 10.21037/apm.2020.04.08
Subject(s) - medicine , transient receptor potential channel , obstructive sleep apnea , transient (computer programming) , cardiology , hypopnea , apnea , receptor , audiology , polysomnography , computer science , operating system
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is recognized as an independent risk factor of cardiovascular disease. The release of Ca2+ mediated by transient receptor potential canonical (TRPC) channels participates in the hypoxia-induced pathophysiological changes in the cardiovascular systems in case of OSAHS. This study aimed to investigate which subtypes of TRPCs were involved in OSAHS in a rat model of intermittent hypoxia.

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