Blueberry polyphenols play a preventive effect on alcoholic fatty liver disease C57BL/6 J mice by promoting autophagy to accelerate lipolysis to eliminate excessive TG accumulation in hepatocytes | Zendy

Qun Zhuge | Zendy; Yi Zhang | Zendy; Biao Liu | Zendy; Mingjuan Wu | Zendy

Open Access

Blueberry polyphenols play a preventive effect on alcoholic fatty liver disease C57BL/6 J mice by promoting autophagy to accelerate lipolysis to eliminate excessive TG accumulation in hepatocytes

Author(s) -

Qun Zhuge,

Yi Zhang,

Biao Liu,

Mingjuan Wu

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm.2020.03.38

Subject(s) - autophagy , steatosis , lipolysis , medicine , alcoholic fatty liver , fatty liver , nonalcoholic fatty liver disease , pathogenesis , polyphenol , lipid metabolism , alcoholic liver disease , disease , biochemistry , adipose tissue , biology , cirrhosis , apoptosis , antioxidant

This study aims to explore blueberry polyphenols and its roles in nonalcoholic fatty liver disease (NAFLD) by relieving hepatic steatosis, and to understand alcoholic fatty liver disease (AFLD). Cell autophagy has been proved to promote lipid metabolism and is involved in the pathogenesis of AFLD; however, whether blueberry polyphenol affects autophagy is unknown. Therefore, our study analyzes the functions of blueberry polyphenol on AFLD and if its mechanisms are engaged with hepatocytes autophagy.

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