L-DOPA-elicited abnormal involuntary movements in the rats damaged severely in substantia nigra by 6-hydroxydopamine | Zendy

Rongfei Wang | Zendy; Ming Shao | Zendy

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L-DOPA-elicited abnormal involuntary movements in the rats damaged severely in substantia nigra by 6-hydroxydopamine

Author(s) -

Rongfei Wang,

Ming Shao

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm.2020.03.32

Subject(s) - substantia nigra , medial forebrain bundle , dyskinesia , medicine , lesion , dopaminergic , nigrostriatal pathway , striatum , dopamine , apomorphine , levodopa , oxidopamine , parkinson's disease , neuroscience , anesthesia , endocrinology , pathology , psychology , disease

Dyskinesia of rat models can occur in several conditions: acute levodopa (L-DOPA) administration provided that the drug dose is sufficiently high and/or that the nigrostriatal dopamine (DA) pathway is seriously damaged, and repeated L-DOPA administration which could cause a reduction of the dyskinesia-threshold dose, a progressive aggravation and an increasing incidence of dyskinesia. Therefore, if the damage of the nigrostriatal DA pathway is extremely severe, what abnormal movements can be elicited by first injecting L-DOPA or other dopaminergic agonists? The problem deserves exploring.

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