MiR-21 antagomir improves insulin resistance and lipid metabolism disorder in streptozotocin-induced type 2 diabetes mellitus rats | Zendy

Yan Wang | Zendy; Lingzhi Yang | Zendy; Da-Gui Yang | Zendy; Qingyi Zhang | Zendy; Zhuo-Na Deng | Zendy; Kao Wang | Zendy; Xing-Jian Mao | Zendy

Open Access

MiR-21 antagomir improves insulin resistance and lipid metabolism disorder in streptozotocin-induced type 2 diabetes mellitus rats

Author(s) -

Yan Wang,

Lingzhi Yang,

Da-Gui Yang,

Qingyi Zhang,

Zhuo-Na Deng,

Kao Wang,

Xing-Jian Mao

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm.2020.02.28

Subject(s) - medicine , endocrinology , insulin resistance , antagomir , adiponectin , type 2 diabetes mellitus , streptozotocin , diabetes mellitus , glucose homeostasis , insulin , downregulation and upregulation , biology , biochemistry , gene

Type 2 diabetes mellitus (T2DM) is a major cause of death with an increasing incidence at an epidemic rate. The existing treatments for T2DM lack long-term effective blood glucose control. In this study, the effects of miR-21 antagomir on T2DM and the related mechanism were investigated using streptozotocin (STZ)-induced T2DM rats.

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