Dynamic evaluation of the correlativity between CD4 cell percentage and FEV1 can predict the balance of the state of the immune system in pulmonary graft versus host disease patients | Zendy

Ting Zhou | Zendy; Lixin Xie | Zendy

Open Access

Dynamic evaluation of the correlativity between CD4 cell percentage and FEV1 can predict the balance of the state of the immune system in pulmonary graft versus host disease patients

Author(s) -

Ting Zhou,

Lixin Xie

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm.2020.02.25

Subject(s) - medicine , hematopoietic stem cell transplantation , disease , immune system , vital capacity , balance (ability) , graft versus host disease , immunology , cardiology , lung , physical therapy , lung function , diffusing capacity

Pulmonary graft versus host disease (GVHD) features irreversible airflow obstruction, which treatment typically involves immunosuppressive regimens. Regardless of whether GVHD is caused by immune overreaction or infection caused by immunologic suppression, the end result is death. Therefore, it is crucial to maintain a balance. We assessed 15 patients after hematopoietic stem cell transplantation (HSCT) in our hospital and collected CD4 cell percentage, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) data from the same period. Here, we present a dynamic evaluation of the correlativity between the CD4 cell percentage and FEV1 that can predict state balance in pulmonary GVHD patients.

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