Open AccessInteraction between valproic acid and carbapenems: decreased plasma concentration of valproic acid and liver injury
Author(s) -
Zhihong Li,
Weiqi Gao,
Guifen Liu,
Zhiling Zhang
Publication year - 2021
Publication title -
annals of palliative medicine
Language(s) - English
Resource type - Journals
eISSN - 2224-5839
pISSN - 2224-5820
DOI - 10.21037/apm-21-795
Subject(s) - valproic acid , medicine , pharmacology , plasma concentration , liver injury , epilepsy , psychiatry
Several case reports and retrospective studies have indicated that carbapenems decrease the plasma concentration of valproic acid (VPA). This retrospective study examines the effect of carbapenems on VPA levels, and explores whether the drug-drug interaction can influence the liver function of patients.
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