All-trans retinoic acid inhibits epithelial-to-mesenchymal transition (EMT) through the down-regulation of IL-6 in endometriosis | Zendy

Luyi Li | Zendy; Hui Gao | Zendy; Liuliu Pan | Zendy; Yu Zhao | Zendy; Zongwen Liang | Zendy; Qiong Zhang | Zendy; Danhan Wang | Zendy

Open Access

All-trans retinoic acid inhibits epithelial-to-mesenchymal transition (EMT) through the down-regulation of IL-6 in endometriosis

Author(s) -

Luyi Li,

Hui Gao,

Liuliu Pan,

Yu Zhao,

Zongwen Liang,

Qiong Zhang,

Danhan Wang

Publication year - 2021

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-21-2175

Subject(s) - stromal cell , clonogenic assay , retinoic acid , cancer research , mesenchymal stem cell , epithelial–mesenchymal transition , medicine , stem cell , gentamicin protection assay , cell , cell culture , biology , pathology , microbiology and biotechnology , metastasis , cancer , biochemistry , genetics

Endometriosis (EMs) is a benign, but potential metastatic, gynecological disease. Our current study aims to examine whether all-trans retinoic acid (ATRA) inhibits the epithelial-to-mesenchymal transition (EMT) of endometriotic stromal stem cells, as well as to explore the mechanisms involved, especially the role of IL-6 played in.

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