Andrographolide protects against endothelial dysfunction and inflammatory response in rats with coronary heart disease by regulating PPAR and NF-κB signaling pathways | Zendy

Jia Shu | Zendy; Ruizhen Huang | Zendy; Ying Tian | Zendy; Yanru Liu | Zendy; Rui Zhu | Zendy; Gang Shi | Zendy

Open Access

Andrographolide protects against endothelial dysfunction and inflammatory response in rats with coronary heart disease by regulating PPAR and NF-κB signaling pathways

Author(s) -

Jia Shu,

Ruizhen Huang,

Ying Tian,

Yanru Liu,

Rui Zhu,

Gang Shi

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-20-960

Subject(s) - andrographolide , medicine , endothelial dysfunction , nitric oxide , endocrinology , inflammation , cholesterol , western blot , apoptosis , peroxisome proliferator activated receptor , high density lipoprotein , lipoprotein , pharmacology , receptor , biochemistry , chemistry , gene

Andrographolide (Andro) is an active compound extracted from Andrographis, which has protective anti-inflammatory effects. But, its pathological role in coronary heart disease (CHD) is unclear, the aim of this study is to investigate the therapeutic effect of Andro in CHD and explore its potential mechanism.

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