Vitamin C attenuates vancomycin induced nephrotoxicity through the reduction of oxidative stress and inflammation in HK-2 cells | Zendy

Wenyun Xu | Zendy; Zhongan Mao | Zendy; Bing Zhao | Zendy; Tongtian Ni | Zendy; Siyu Deng | Zendy; Ping Yu | Zendy; Juan He | Zendy; Enqiang Mao | Zendy

Open Access

Vitamin C attenuates vancomycin induced nephrotoxicity through the reduction of oxidative stress and inflammation in HK-2 cells

Author(s) -

Wenyun Xu,

Zhongan Mao,

Bing Zhao,

Tongtian Ni,

Siyu Deng,

Ping Yu,

Juan He,

Enqiang Mao

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-20-694

Subject(s) - oxidative stress , nephrotoxicity , lipid peroxidation , superoxide dismutase , sod2 , medicine , pharmacology , inflammation , viability assay , vitamin c , glutathione , kidney , apoptosis , biochemistry , immunology , endocrinology , chemistry , enzyme

Oxidative stress is one of the possible mechanisms in vancomycin (VCM) induced nephrotoxicity. Some studies suggested that high dose Vitamin C (VC) has protective effect against the nephrotoxicity in mice, but the underlying molecular mechanism is not mentioned. We investigated the potential targets of high dose VC against oxidative stress and inflammation induced by VCM in renal tubular epithelial cells.

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