Effect of Tang-Shen-Ning decoction on podocyte epithelial-esenchymal transformation via inhibiting Wnt/β-catenin pathway in diabetic mice | Zendy

Fang-qiang Cui | Zendy; Yanbin Gao | Zendy; Yue-Fen Wang | Zendy; Meng Yuan | Zendy; Zhen Cai | Zendy; Cun Shen | Zendy; Xin-Can Jiang | Zendy; Wenjing Zhao | Zendy

Open Access

Effect of Tang-Shen-Ning decoction on podocyte epithelial-esenchymal transformation via inhibiting Wnt/β-catenin pathway in diabetic mice

Author(s) -

Fang-qiang Cui,

Yanbin Gao,

Yue-Fen Wang,

Meng Yuan,

Zhen Cai,

Cun Shen,

Xin-Can Jiang,

Wenjing Zhao

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-20-602

Subject(s) - podocyte , nephrin , wnt signaling pathway , synaptopodin , desmin , western blot , medicine , endocrinology , creatinine , diabetic nephropathy , proteinuria , signal transduction , biology , kidney , microbiology and biotechnology , immunohistochemistry , biochemistry , vimentin , gene

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). Podocyte epithelial-esenchymal transformation (EMT) induced by the activated Wnt/β-catenin pathway plays a key role in DN. Tang-Shen-Ning (TSN), a Chinese herbal formula, has been shown to decrease proteinuria and protect the renal function in DN. However, the effect of TSN on the Wnt/β-catenin pathway and podocyte EMT is unclear.

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