Validation of the protective effects of Lonicera japonica polysaccharide on lipopolysaccharide-induced learning and memory impairments via regulation of autophagy based on network pharmacology | Zendy

Jiandong Wang | Zendy; Ping Liu | Zendy; Xiaobo Huang | Zendy; Xiling Wu | Zendy

Open Access

Validation of the protective effects of Lonicera japonica polysaccharide on lipopolysaccharide-induced learning and memory impairments via regulation of autophagy based on network pharmacology

Author(s) -

Jiandong Wang,

Ping Liu,

Xiaobo Huang,

Xiling Wu

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-20-357

Subject(s) - kegg , autophagy , medicine , lipopolysaccharide , nissl body , traditional chinese medicine , systems pharmacology , pharmacology , neuroprotection , gene , neuroscience , biology , transcriptome , biochemistry , gene expression , immunology , staining , apoptosis , pathology , drug , alternative medicine

Learning and memory impairments are important indexes in assessing Alzheimer's disease (AD). Lonicera japonica (L. japonica), a traditional Chinese herbal medicine, inhibits inflammation, but its role in neuroprotection is unclear. Polysaccharide is the main active ingredient in L. japonica. Here, we aimed to validate the effects of L. japonica polysaccharide (LJP) on lipopolysaccharide (LPS)-induced cognitive impairment and the underlying mechanism.

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