Gandou decoction, a Chinese medicinal formula, in the treatment of hepatic injury by Wnt/β-catenin pathway regulation in models of Wilson disease | Zendy

Manli Gao | Zendy; Hao Geng | Zendy; Peng Wu | Zendy; Jianjian Dong | Zendy; Hai Li | Zendy; Chenchen Xu | Zendy; Bo Li | Zendy; Yongzhu Han | Zendy; Nan Cheng | Zendy

Open Access

Gandou decoction, a Chinese medicinal formula, in the treatment of hepatic injury by Wnt/β-catenin pathway regulation in models of Wilson disease

Author(s) -

Manli Gao,

Hao Geng,

Peng Wu,

Jianjian Dong,

Hai Li,

Chenchen Xu,

Bo Li,

Yongzhu Han,

Nan Cheng

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-20-301

Subject(s) - medicine , decoction , disease , wnt signaling pathway , catenin , traditional medicine , traditional chinese medicine , pharmacology , pathology , signal transduction , alternative medicine , microbiology and biotechnology , biology

Gandou decoction (GDD) has been widely used in the treatment of Wilson disease (WD) for decades. It is optimized from the Dahuanghuanglianxiexin decoction, Yinchenhao decoction, and Huanglianjiedu decoction. It was first reported in the Treatise on Febrile and Miscellaneous Diseases and A Handbook of Prescriptions for Emergencies published in the Eastern Han Dynasty and the Eastern Jin Dynasty respectively. Hepatic injury is one of the most severe complications of WD. The current study aimed to explore the hepatic-protection effects of GDD and its exact therapeutic target, with a particular focus on the expression of oxidative stress and the Wnt/β-catenin pathway.

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