Ligustrazine induces the colorectal cancer cells apoptosis via p53-dependent mitochondrial pathway and cell cycle arrest at the G0/G1 phase | Zendy

Yaoyao Bian | Zendy; Lili Yang | Zendy; Wei Sheng | Zendy; Zhengjun Li | Zendy; Yu Xu | Zendy; Wenlin Li | Zendy; Li Zeng | Zendy

Open Access

Ligustrazine induces the colorectal cancer cells apoptosis via p53-dependent mitochondrial pathway and cell cycle arrest at the G0/G1 phase

Author(s) -

Yaoyao Bian,

Lili Yang,

Wei Sheng,

Zhengjun Li,

Yu Xu,

Wenlin Li,

Li Zeng

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-20-288

Subject(s) - cell cycle checkpoint , cell cycle , apoptosis , g1 phase , cell growth , flow cytometry , microbiology and biotechnology , cell , viability assay , cancer research , medicine , biology , biochemistry

Ligustrazine, active ingredients extracted from the natural herb Ligusticum Chuanxiong Hort, has promising anti-tumor properties on tumor cell lines. However, the potential anti-tumor activity of ligustrazine on colorectal cancer (CRC) cells and the molecular mechanisms have not been elucidated. In this study, we explored the critical functions of ligustrazine on SW480 and CT26 cells at cellular levels.

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