Open AccessHyperbaric oxygen therapy cognitive function in a rat model of mild cognitive impairment via ERK signaling
Author(s) -
Yuerong Lin,
Xianzhong Lin,
Xiaohong Zheng,
Fang Liu,
Chen Ye,
Linshen Huang,
Qian Zhou,
Ting Chen,
Lanying Lin
Publication year - 2020
Publication title -
annals of palliative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 19
eISSN - 2224-5839
pISSN - 2224-5820
DOI - 10.21037/apm-20-1716
Subject(s) - medicine , hippocampal formation , mapk/erk pathway , morris water navigation task , neuroprotection , h&e stain , apoptosis , cognition , hippocampus , pathological , kinase , pharmacology , anesthesia , endocrinology , immunohistochemistry , biochemistry , biology , psychiatry
The development of novel treatment strategies to reverse or impede cognitive dysfunction associated with mild cognitive impairment (MCI) has gained attention in recent times. Meanwhile, hyperbaric oxygen (HBO) has been widely used as a neuroprotective therapy that can promote recovery of damaged neurons. The aim of this study was to investigate the effects of HBO on cognitive function in rats with MCI and to clarify the associated mechanisms.
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