The clinical significance of the SIRT2 expression level in the early stage of sepsis patients | Zendy

Hua Xu | Zendy; Xin Yu | Zendy; Bin Wang | Zendy; Huihong Zhang | Zendy; Jiafu Li | Zendy; Hongmei Gao | Zendy; Yongqiang Wang | Zendy

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The clinical significance of the SIRT2 expression level in the early stage of sepsis patients

Author(s) -

Hua Xu,

Xin Yu,

Bin Wang,

Huihong Zhang,

Jiafu Li,

Hongmei Gao,

Yongqiang Wang

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-19-653

Subject(s) - sirt2 , medicine , sepsis , lipopolysaccharide , inflammation , expression (computer science) , clinical significance , stimulation , sirtuin , immunology , genetics , gene , biology , acetylation , computer science , programming language

Sirtuin2 (SIRT2), one of the members of the sirtuins family, has been proven to be a conserved protein. SIRT2 is reported to be associated with infection and inflammation, and its expression level in some cells such as mice brain can be reduced by the stimulation of lipopolysaccharide (LPS). We surmise that the expression levels of SIRT2 may be a warning signal of sepsis in the human body.

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