The role of TRPC6 in α1-AR activation-induced calcium signal changes in human podocytes | Zendy

Derun Wang | Zendy; Qin Wang | Zendy; Tianrong Ji | Zendy; Yang He | Zendy; Fanwu Kong | Zendy; Jundong Jiao | Zendy

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The role of TRPC6 in α1-AR activation-induced calcium signal changes in human podocytes

Author(s) -

Derun Wang,

Qin Wang,

Tianrong Ji,

Yang He,

Fanwu Kong,

Jundong Jiao

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-19-602

Subject(s) - medicine , trpc6 , calcium , microbiology and biotechnology , cancer research , endocrinology , receptor , transient receptor potential channel , biology

An accumulating amount of evidence has suggested that there is a contributive role of sympathetic nervous hyperactivity in the pathogenesis of chronic kidney disease (CKD). α1-AR promotes an increase in calcium levels in podocytes and adjusts podocyte contraction. Changes in TRPC6 expression and function can directly affect the podocyte cytoskeleton, which is a key component in podocyte injury. This study proposed to clarify the correlation between α1-AR activation-induced signal cascade reaction and TRPC6 in human podocytes.

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