Effect of immunotherapy on patients with unexplained recurrent spontaneous abortion | Zendy

Jiao Chen | Zendy; Bowen Liu | Zendy; Ying Zhang | Zendy; Liangfei Ao | Zendy; Zehong Li | Zendy; Bing Qu | Zendy; Xueyao Li | Zendy; Jing Yang | Zendy

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Effect of immunotherapy on patients with unexplained recurrent spontaneous abortion

Author(s) -

Jiao Chen,

Bowen Liu,

Ying Zhang,

Liangfei Ao,

Zehong Li,

Bing Qu,

Xueyao Li,

Jing Yang

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-19-440b

Subject(s) - medicine , abortion , active immunotherapy , immunotherapy , live birth , pregnancy , blocking antibody , active immunization , lymphocyte , antibody , immunization , immune system , immunology , genetics , biology

At present, it is generally believed that immune factors account for 60% of unexplained recurrent spontaneous abortion (URSA). The treatments used for URSA depend on immunomodulation for their effects, and paternal immunization, intravenous immunoglobulin, and the use of growth factors such as granulocyte-colony stimulating factor (filgrastim) have been shown to have a beneficial effect on patients with a poor prognosis. However, these treatment schemes and effects remain controversial. This study aimed to evaluate the effect of immunotherapy using lymphocyte active immunotherapy (LAI) on patients with URSA, and to provide evidences for the clinical effect of this treatment.

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