Plasma cell leukemia characterized by EDTA-dependent plasma cell agglutination: a case report

Primary plasma cell leukemia (PPCL) is one of the most challenging diseases for hematologists. A 65-year-old Chinese male with a history of chronic kidney disease and anemic appearance was admitted. He was diagnosed with plasma cell leukemia. Peripheral blood cells smearing showed piles of plasma cells with cloud-like agglutination. EDTA-dependent plasma cells agglutination is a rare phenomenon in vitro. We reported a case of plasma cell leukemia characterized by plasma cell agglutination, which has never been reported. This case reminded the laboratory physicians who master the blood cell analyzer should have the ability to comprehensively diagnose hematological diseases, and at the same time strictly implement the "Re-examination Rules for Blood Cells".