No association between the COMT Val158Met polymorphism and cognitive training response in healthy Shanghai community-dwelling elderly individuals | Zendy

Wei Feng | Zendy; Ze Yu | Zendy; Shunying Yu | Zendy; Wenyuan Wu | Zendy; Jennifer S. Yokoyama | Zendy; Chunbo Li | Zendy

Open Access

No association between the COMT Val158Met polymorphism and cognitive training response in healthy Shanghai community-dwelling elderly individuals

Author(s) -

Wei Feng,

Ze Yu,

Shunying Yu,

Wenyuan Wu,

Jennifer S. Yokoyama,

Chunbo Li

Publication year - 2020

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm-19-416

Subject(s) - rs4680 , medicine , cognition , neuropsychology , catechol o methyl transferase , cognitive training , gerontology , clinical psychology , physical therapy , psychiatry , allele , chemistry , biochemistry , gene

Cognitive training may have an effect on promoting the maintenance of cognitive functions in healthy elderly adults. The catechol-O-methyltransferase (COMT) variant Val158Met (rs4680) is a wellstudied functional variant that has been associated with differences in cognitive functions. Whether this COMT polymorphism is associated with cognitive performance after training remains unknown. We tested whether the COMT Val158Met polymorphism could influence the cognitive function over time in healthy community-dwelling elderly adults who participated in a multi-domain cognitive training intervention.

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