IMPROVING EFFECT OF PLATYCODIN D ON ETHANOL-INDUCED FATTY LIVER VIA KEAP1-NRF2-ARE SIGNAL PATH | Zendy

Jingtao Wu | Zendy; Lei Zhou | Zendy; Guiwen Yang | Zendy; Tao Fan | Zendy; Maoshan Wang | Zendy; Jianguo Hu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

IMPROVING EFFECT OF PLATYCODIN D ON ETHANOL-INDUCED FATTY LIVER VIA KEAP1-NRF2-ARE SIGNAL PATH

Author(s) -

Jingtao Wu,

Lei Zhou,

Guiwen Yang,

Tao Fan,

Maoshan Wang,

Jianguo Hu

Publication year - 2017

Publication title -

african journal of traditional complementary and alternative medicines

Language(s) - English

Resource type - Journals

eISSN - 2505-0044

pISSN - 0189-6016

DOI - 10.21010/ajtcam.vi15.1.15

Subject(s) - antioxidant , chemistry , enzyme , ethanol , oxidative stress , fatty liver , traditional medicine , biochemistry , medicine , disease

Background: Platycodin D (PD) is one of the important active ingredients in the root of the Platycodon grandiflorum (Jacq.) A. DC (PG), a traditional medicine with many pharmacological activities, especially hepatoprotective activity. There are some researches on the mechanism of liver protection, but it is not very clear. It is necessary to investigate it deeply. Materials and Methods: In order to evaluate the effect of PD on ethanol-induced fatty liver (EFL) and investigate the possible mechanism, the EFL models of rats and BRL-3A cells were set up and treated with PD of 20, 30 mg/kg body weight/day for four weeks, respectively. The hepatic histochemistry, liver function enzymes, oxidative stress levels, antioxidant enzymes and signal path enzymes were assayed. Results: PD significantly (P

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research