Fabrication of 3D Photoresist Structure for Artificial Capillary Blood Vessel

We propose a new method for fabricating artificial capillaries using direct laser writing. IP-L and Ormocomp are tested as photoresist materials. Three different microstructures were fabricated from IP-L: a porous hollow pipe microstructure, a 3 × 3 array of twig microstructures, and an array of hollow twig microstructures. Porous hollow pipe microstructures of different diameters were fabricated from Ormocomp, a biocompatible photoresist. These designs resemble capillaries. IP-L and Ormocomp fabrication parameters, such as laser power, numerical aperture, fabrication time, and fabrication model, are compared. Fabrication time is related to the fabrication model chosen during the direct laser writing process. Combined model fabrication is recommended over solid model fabrication because it results in shorter fabrication time and a more robust microstructure that is more likely to maintain its shape on the substrate after development. Laser power is another important parameter controlling fabrication. IP-L fabrication withstands up to 20 mW of laser power, unlike Ormocomp microstructures, which require laser power of less than 18 mW. IP-L and Ormocomp photoresist stiffness is also evaluated. The fabrication of artificial capillaries is important in developing vascular simulators that enable researchers to understand, for example, blood pressure in the kidney glomerulus.