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2DOF Magnetically Driven Microtool for Soft Peeling of Zona Pellucida
Author(s) -
Yoko Yamanishi,
Tomohiro Kawahara,
Tomohiro Iyanagi,
Masaya HAGIWARA,
Takehito Mizunuma,
Naoki Inomata,
Shogo Kudo,
Fumihito Arai
Publication year - 2010
Publication title -
journal of robotics and mechatronics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 19
eISSN - 1883-8049
pISSN - 0915-3942
DOI - 10.20965/jrm.2010.p0623
Subject(s) - zona pellucida , oocyte , microfluidics , microfluidic chip , cloning (programming) , chip , process (computing) , materials science , throughput , computer science , biomedical engineering , nanotechnology , biology , microbiology and biotechnology , engineering , telecommunications , embryo , programming language , operating system , wireless
We automated removal of the swine oocyte zona pellucida using a 2DOF magnetically driven microtool (MMT) on a microfluidic chip. Multiple oocytes can be manipulated simultaneously highly stably, providing strong advantages over conventional manual manipulation using pipetting. We propose automating this process by activating a soft polymer microtool on a disposable microfluidic chip to stably mass-produce peeled oocytes - a breakthrough in high throughput and effective oocyte manipulation in cloning and fertility treatment.

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