Microfluidic Device with Integrated Glucose Sensor for Cell-Based Assay in Toxicology | Zendy

Hiroshi Kimura | Zendy; Hirokazu Takeyama | Zendy; Kikuo Komori | Zendy; Takatoki Yamamoto | Zendy; Yasuyuki Sakai | Zendy; Teruo Fujii | Zendy

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Microfluidic Device with Integrated Glucose Sensor for Cell-Based Assay in Toxicology

Author(s) -

Hiroshi Kimura,

Hirokazu Takeyama,

Kikuo Komori,

Takatoki Yamamoto,

Yasuyuki Sakai,

Teruo Fujii

Publication year - 2010

Publication title -

journal of robotics and mechatronics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.257

H-Index - 19

eISSN - 1883-8049

pISSN - 0915-3942

DOI - 10.20965/jrm.2010.p0594

Subject(s) - microfluidics , drug discovery , cell , biomedical engineering , nanotechnology , computer science , materials science , chemistry , medicine , biochemistry

We have developed a cell-based assay platform using a microfluidic device integrating a glucose sensor into a cell culture device with closed-loop perfusion. Online measurement of cell kinetic change associated with cell status change was achieved by measuring glucose concentration change in the device with a cell exposed to a toxic material. The cell-based assay platform, which is integrated with a sensor and a perfusion system, was expected to improve measurement accuracy and efficiency, leading to the discovery of new tools in such wide-ranging fields as drug discovery, life sciences, and medical research.

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