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ASSESSMENT OF MICRONUCLEUS AND OXIDATIVE STRESS IN PERIPHERAL BLOOD FROM MALNOURISHED CHILDREN
Author(s) -
Leonor Rodrı́guez,
Elsa CervantesRíos,
Mina Königsberg-Fainstein,
Jaime Graniel-Guerrero,
Rocı́o Ortiz
Publication year - 2018
Publication title -
nutrición hospitalaria
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 53
eISSN - 1699-5198
pISSN - 0212-1611
DOI - 10.20960/nh.1272
Subject(s) - oxidative stress , lipid peroxidation , superoxide dismutase , glutathione peroxidase , antioxidant , micronucleus test , micronucleus , medicine , physiology , malnutrition , population , immunology , andrology , biology , biochemistry , toxicity , environmental health
malnutrition is one of the most common health problems among children in underdeveloped countries, including Mexico. Previous studies have indicated increased genetic damage in malnourished humans and animal models, but the essential mechanisms remain unclear. In the present study, we assessed the effects of malnutrition on the frequency of micronucleus (MN) in reticulocytes (RET) from the peripheral blood of well-nourished uninfected (WN), well-nourished infected (WNI), moderately malnourished infected (UNM) and severely malnourished infected (UNS) children. Moreover, lipid peroxidation and the antioxidant status were evaluated to investigate the role of oxidative processes in malnutrition-associated genotoxicity.

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