Effect of an aqueous extract of Chrysobalanus icaco on the adiposity of Wistar rats fed a high-fat diet | Zendy

Heloisa Helena Pessoa Portela-de-Sá | Zendy; Paula Alexandre de Freitas | Zendy; Keciany Alves | Zendy; Yuri Vasconcelos | Zendy; Renata Prado Vasconcelos | Zendy; Said Gonçalves da Cruz Fonseca | Zendy; Edgleyson C. Santos | Zendy; Edivânia Oliveira Bezerra Pontes | Zendy; Carla Soraya Costa Maia | Zendy; Andrelioronha CoelhodeSouza | Zendy; José Henrique LealCardoso | Zendy; Luciana Catunda Brito | Zendy; Ariclécio Cunha de Oliveira | Zendy

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Effect of an aqueous extract of Chrysobalanus icaco on the adiposity of Wistar rats fed a high-fat diet

Author(s) -

Heloisa Helena Pessoa Portela-de-Sá,

Paula Alexandre de Freitas,

Keciany Alves,

Yuri Vasconcelos,

Renata Prado Vasconcelos,

Said Gonçalves da Cruz Fonseca,

Edgleyson C. Santos,

Edivânia Oliveira Bezerra Pontes,

Carla Soraya Costa Maia,

Andrelioronha CoelhodeSouza,

José Henrique LealCardoso,

Luciana Catunda Brito,

Ariclécio Cunha de Oliveira

Publication year - 2020

Publication title -

nutrición hospitalaria

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.31

H-Index - 53

eISSN - 1699-5198

pISSN - 0212-1611

DOI - 10.20960/nh.03030

Subject(s) - lipogenesis , adipose tissue , aqueous extract , medicine , endocrinology , glycemic , body weight , saline , chemistry , traditional medicine , diabetes mellitus

Objective: the purpose of this study was to investigate the effects of Chrysobalanus icaco on adiposity and its mechanism of action in the gene and protein expression of acetyl-CoA carboxylase (ACC), a key enzyme in lipogenesis. Method: Wistar rats were divided into a regular or control group (CG) and a high-fat diet (HFD) group. HFD was treated with saline or aqueous extract of Chrysobalanus icaco (AECI) for four weeks. Body weight and food intake were assessed. Subcutaneous, retroperitoneal and periepididymal adipose tissue samples were collected and weighed. Adipocytes from periepididymal tissue were isolated and analyzed. The gene and protein expression of ACC in subcutaneous tissue was determined. Results: AECI showed no effect on intake or body weight. However, the weight of the fat pads and the gene and protein expression of ACC were lower, and glucose tolerance was improved. Conclusion: the aqueous extract of Chrysobalanus icaco proved beneficial for the treatment of obesity, preventing fat storage and improving glycemic homeostasis.

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