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Standard antidepressants typically have a limited treatment response rate. Only approximately one-third of patients diagnosed with depression will respond to their first antidepressant, and the remaining two-third will not respond to their antidepressants[1]. Moreover, during the latency period, the risk of suicide and self-harm significantly increases, whichrepresents a key public health issue in psychiatric practice [2].

The Need for Genetic Predictors for Antidepressant Actions of Ketamine or Ketamine Metabolites