Przegląd badań oceniających wpływ czynników żywieniowych na poziom ekspresji lncRNA, których mechanizmy epigenetyczne potencjalnie mogą brać udział w przebiegu raka jajnika

Research suggests that increased expression of long noncoding RNAs is a factor that can affect tumour size, and the level of their expression may depend on the increased fat intake, which can lead to obesity. The aim of this work was assessment of the impact of nutritional intervention on the level of lncRNA expression. The PubMed and ScienceDirect bases were searched from December 31, 2018 to January 23, 2019 in order to fi nd works that concern the effect of nutrition on the level of lncRNA expression. The following keywords were used: lncRNA + high fat diet (720 publications), lncRNA + obesity (142 publications), lncRNA + dietary (480 publications). 1342 works were found. No studies with the participation of people were found. The study excluded the works in which information was not provided on how to divide groups of test animals, prepare feed or measure the expression of lncRNA after the introduction of a specifi c diet. The review included 4 animal studies, in which a nutritional intervention was used and its impact on the level of lncRNA expression was assessed, and information about the duration of the study and the level of expression of the studied lncRNA were included. Research shows that the use of high fat food (25% of fat) may contribute to a statistically signifi cant increase or decrease in the level of the lncRNA. Studies indicate that higher fat content in food intake may affect the level of lncRNA expression lacking the protein coding potential.