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A 70-year-old man underwent endoscopic submucosal dissection (ESD) for a small mucosal adenocarcinoma on the posterior wall of the angular incisure of the stomach. The lesion was removed completely without any complications. The next morning, the patient experienced severe abdominal pain of sudden onset and was found to have tenderness in the upper abdomen. Computed tomography showed free air without fluid collection in the abdominal cavity. Emergency endoscopy was performed 3 h after the onset of the pain. A 10-mm perforation was found on the post-ESD wound (Fig. 1) and was completely closed with 2 over-the-scope-clips (OTSC; Ovesco Endoscopy, Tübingen, Germany) (Fig. 2). No extraluminal leak of diatrizoate meglumine was detected during upper gastrointestinal examinations on post-procedural day 5. The patient started food intake on post-procedural day 6 and was discharged on post-procedural day 15. The OTSCs were visible at the scar on surveillance endoscopy 2 months later. Most patients with delayed perforation require emergency surgery [1,2]. Patients with localized peritonitis may respond to conservative therapy [1,3], but how to close a large and vulnerable perforation remains an issue. In this patient, the perforation site was completely closed with the OTSCs before severe pan-peritonitis had developed, thus avoiding emergency surgery.

Delayed perforation after gastric endoscopic submucosal dissection can be treated by using over-the-scope clips