Comments on “The severity of non-alcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota” | Zendy

Anna Egresi | Zendy; Krisztina Hagymási | Zendy; Gabriella Lengyel | Zendy

Open Access

Comments on “The severity of non-alcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota”

Author(s) -

Anna Egresi,

Krisztina Hagymási,

Gabriella Lengyel

Publication year - 2016

Publication title -

hepatoma research

Language(s) - English

Resource type - Journals

eISSN - 2454-2520

pISSN - 2394-5079

DOI - 10.20517/2394-5079.2016.31

Subject(s) - medicine , fatty liver , dysbiosis , gut flora , pathogenesis , gastroenterology , disease , pathology , physiology , bioinformatics , immunology , biology

Non-alcoholic fatty liver disease (NAFLD) has a rising prevalence worldwide. It is characterized with lipid deposition in hepatocytes that is unrelated to alcohol consumption. Insulin resistance and oxidative damage plays a key role in its pathogenesis. NAFLD is a complex disease, classified in simple steatosis (SS) and non-alcoholic steatohepatitis (NASH). Lifestyle changes and treatment of hyperinsulinaemia could reverse SS. However, 20-30% of NAFLD patients develop to NASH, which could lead to liver fibrosis, cirrhosis and cancer.

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