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Non-alcoholic fatty liver disease (NAFLD) has a rising prevalence worldwide. It is characterized with lipid deposition in hepatocytes that is unrelated to alcohol consumption. Insulin resistance and oxidative damage plays a key role in its pathogenesis. NAFLD is a complex disease, classified in simple steatosis (SS) and non-alcoholic steatohepatitis (NASH). Lifestyle changes and treatment of hyperinsulinaemia could reverse SS. However, 20-30% of NAFLD patients develop to NASH, which could lead to liver fibrosis, cirrhosis and cancer.

hepatoma research

Comments on “The severity of non-alcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota”