Hepatocellular carcinoma and type 2 diabetes mellitus: cytokeratin 8/18 expression in hepatocellular carcinoma and glycogen-storing hepatocytes | Zendy

Kunio Takegoshi | Zendy; Eikichi Okada | Zendy; Qin Su | Zendy

Open Access

Hepatocellular carcinoma and type 2 diabetes mellitus: cytokeratin 8/18 expression in hepatocellular carcinoma and glycogen-storing hepatocytes

Author(s) -

Kunio Takegoshi,

Eikichi Okada,

Qin Su

Publication year - 2016

Publication title -

hepatoma research

Language(s) - English

Resource type - Journals

eISSN - 2454-2520

pISSN - 2394-5079

DOI - 10.20517/2394-5079.2016.26

Subject(s) - hepatocellular carcinoma , cytokeratin , medicine , pathogenesis , diabetes mellitus , type 2 diabetes mellitus , carcinoma , glycogen , gastroenterology , cancer research , oncology , pathology , immunohistochemistry , endocrinology

Cytokeratins (CKs), the intermediate filament (IF) proteins of epithelia, are sub-divided into type I (CK9-20) and type II (CK1-8) and expressed as type I/II pairs in a cell differentiation manner. In adult liver, hepatocyte IF comprise only CK8/18.[3] CK8/18 expression in normal and diseased liver has been reported, including positive expression in alcoholic steatohepatitis (ASH) and/or non-alcoholic steatohepatitis (NASH) and HCC.[3]

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