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The periocular area is one of the first regions of the body to show signs of aging, which include static and dynamic rhytids as well as subcutaneous volume loss. The complex anatomy and dynamic underlying muscles of facial expression make this region particularly difficult to treat. Botulinum toxins and fillers, especially when used in combination, offer an excellent approach to minimally invasive rejuvenation of this area. This article aims to present a basic overview and clinical primer for the use of these injectables along with advice on avoiding and managing common complications.

Periocular rejuvenation with neurotoxin and dermal filler