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The application of stem cells technology to the intractable disease has emerged in the 21st century. It has been applied to almost all areas of medicine, including cardiovascular, nervoulogic, hematologic, genetic, liver, endocrine and musculoskeletal diseases. In particular, stem cell mediated tissue regeneration has opened treatment options for previously-considered intractable diseases, with no other treatment alternatives.

Comment on “Multipotency and secretome: the mechanisms behind the regenerative potential of adipose-derived stem cells”