Some Patients Experience Both Chronic Lymphocytic Leukemia And A Non-Hematologic Malignancy

OZET: Kanser hastalari, ortak risk faktorleri ya da onceki malignite tedavisinin karsinojenik etkisiyle diger maligniteler icin artmis risk tasirlar. Cogu malignite icin sagkalim oranlari arttigindan birden fazla malignitesi olan hasta sayisi da artmaktadir. Kronik lenfositik losemi (KLL) de solid tumor ve diger lenfoid malignitelerin riskinde artisla birliktelik gosterir fakat bu iliskinin mekanizmasi net degildir. Bu yazida KLL ve hematolojik olmayan maligniteli hastalarimizi geriye donuk olarak degerlendirdik. Hem KLL hem de hematolojik olmayan maligniteli 11 hastamiz mevcuttu. Hastalarin sadece klinik ve laboratuvar ozelliklerini degil sitogenetik sonuclarini da sunduk. Amacimiz bu hastalardaki nedensel faktorlerin rolune ve tedavi seceneklerine katki saglamaktir. ANAHTAR KELIMELER: Kronik lenfositik losemi, hematolojik olmayan malignite, risk faktorleri, sitogenetik SUMMARY: Cancer patients are often at increased risk for other malignancies due to shared risk factors or carcinogenecity of the treatment for prior malignancy. As survival rates for most malignancies are increasing, the number of patients with more than one malignancy is also increasing. In this report we evaluated our patients having both chronic lymphoytic leukemia (CLL) and a non-hematologic malignancy retrospectively. We had 11 patients having both CLL and a non-hematologic malignancy. We aimed to add new insights into the role of casual factors and treatment options by reporting our patients with CLL and a non-hematologic malignancy. KEYWORDS: Chronic lymphocytic leukemia, cytogenetics, non-hematologic malignancy, risk factors