Open AccessEffects of treadmill exercise on PI3K/AKT/GSK-3β pathway and tau protein in high-fat diet-fed rats
Author(s) -
Jaehoon Jeong,
EunBum Kang
Publication year - 2018
Publication title -
physical activity and nutrition
Language(s) - English
Resource type - Journals
eISSN - 2233-6842
pISSN - 2233-6834
DOI - 10.20463/jenb.2018.0002
Subject(s) - protein kinase b , pi3k/akt/mtor pathway , medicine , endocrinology , chemistry , phosphorylation , signal transduction , biochemistry
This study aimed to clearly evaluate the effects of obesity on cerebral health. Thus, we induced obesity in rats using a long-term high-fat diet (HFD), then investigated its effects on insulin signaling and tau hyperphosphorylation. Additionally, we examined the effects of 8 weeks of treadmill exercise (TE) on insulin signaling and tau hyperphosphorylation.
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