Association of exercise-induced autophagy upregulation and apoptosis suppression with neuroprotection against pharmacologically induced Parkinson's disease
Author(s) -
Yong Chul Jang,
Dong Joo Hwang,
Jung Hoon Koo,
Hyun Seob Um,
Nam Hee Lee,
Dong Cheol Yeom,
Youngil Lee,
Joon Yong Cho
Publication year - 2018
Publication title -
physical activity and nutrition
Language(s) - English
Resource type - Journals
eISSN - 2233-6842
pISSN - 2233-6834
DOI - 10.20463/jenb.2018.0001
Subject(s) - mptp , autophagy , neuroprotection , apoptosis , neurotoxin , parkinson's disease , tyrosine hydroxylase , downregulation and upregulation , pharmacology , pink1 , chemistry , endocrinology , medicine , biochemistry , dopamine , disease , mitophagy , gene
We investigated whether treadmill exercise (TE)-induced neuroprotection was associated with enhanced autophagy and reduced apoptosis in a mouse model of pharmacologically induced Parkinson's disease (PD).
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