Cytotoxic‑based assays in delayed drug hypersensitivity reactions induced by antiepileptic drugs | Zendy

Grzegorz Porębski | Zendy; Ewa Czarnobilska | Zendy; Magdalena Bosak | Zendy

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Cytotoxic‑based assays in delayed drug hypersensitivity reactions induced by antiepileptic drugs

Author(s) -

Grzegorz Porębski,

Ewa Czarnobilska,

Magdalena Bosak

Publication year - 2015

Publication title -

polskie archiwum medycyny wewnętrznej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 35

eISSN - 1897-9483

pISSN - 0032-3772

DOI - 10.20452/pamw.3160

Subject(s) - perforin , cytotoxic t cell , medicine , granzyme b , granulysin , immunology , pharmacology , drug , flow cytometry , peripheral blood mononuclear cell , in vitro , cd8 , immune system , biology , biochemistry

INTRODUCTION Cytotoxic mechanisms are present in the majority of delayed drug hypersensitivity reactions, but are not used as a diagnostic tool. OBJECTIVES The aim of the study was to compare cytotoxic‑based assays with a proliferation assay and drug patch tests in patients with maculopapular eruptions induced by antiepileptic drugs.

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