Open AccessOncolytic virus – an effective targeting therapy for cancer treatment
Author(s) -
Khue Gia Nguyen,
Dang Quan Nguyen,
Le Xuan Truong Nguyen
Publication year - 2014
Publication title -
vietnam journal of science
Language(s) - English
Resource type - Journals
ISSN - 2374-8664
DOI - 10.20328/vjsonline.2015.rr3
Subject(s) - oncolytic virus , cancer therapy , medicine , cancer treatment , virus , viral therapy , cancer , virology , oncology , cancer research , covid-19 , disease , infectious disease (medical specialty)
The oncolytic viruses that were discovered in the late of 19th century have been recently considered as an effective anti-cancer therapy due to its selective replication activity in cancer cells. Currently, at least nine types of virus have been studied in clinical trials for treating a variety of cancers including T-VEC and Reolysin. In this review, we focus on historical researches of oncolytic viruses. We also describe the molecular mechanism of oncolytic viruses in cancer cells. Positive clinical trial results strongly suggest oncolytic viruses as an effective targeting virotherapy for treating cancer. Editor: Mai Tran Ph.D., International University, Ho Chi Minh city National University
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