Open AccessAnti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)
Author(s) -
Ki Sun Kwon,
Hyun Lim,
Yong Soo Kwon,
Hye Ri Choi,
Myong Jo Kim,
Ji Hye Yoo,
Nam Ho Yoo,
Hyun Pyo Kim
Publication year - 2019
Publication title -
natural product sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.322
H-Index - 25
eISSN - 2288-9027
pISSN - 1226-3907
DOI - 10.20307/nps.2019.25.4.304
Subject(s) - rheumatoid arthritis , arthritis , medicine , nitric oxide , inflammation , pharmacology , mechanism of action , nitric oxide synthase , tumor necrosis factor alpha , lipopolysaccharide , immunology , chemistry , biochemistry , in vitro
The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in lipopolysaccharide-treated macrophages, RAW 264.7 cell. OE reduces inducible nitric oxide (NO) synthase-induced NO production, and interferes with mitogen-activated protein kinase activation pathways. In the present study, the pharmacological action of the water extract of OE was examined to establish anti-arthritic action, using a rat model of adjuvant-induced arthritis (AIA). The water extract of OE administered orally inhibited AIAinduced arthritis at (100 - 300) mg/kg/day. The paw edema was significantly decreased, in combination with reduced production of pro-inflammatory cytokines. The action mechanism includes an inhibition of MAPKs/ nuclear transcription factor-κB activation. These new findings strongly suggest that OE possesses anti-arthritic action, and may be used as a therapeutic agent in inflammation-related disorders, particularly in arthritic condition.
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