Acetylcholinesterase Inhibitors from Angelica polymorpha Stem | Zendy

Yong-Soo Kwon | Zendy; Hyun Pyo Kim | Zendy; Myong Jo Kim | Zendy; Wanjoo Chun | Zendy

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Acetylcholinesterase Inhibitors from Angelica polymorpha Stem

Author(s) -

Yong-Soo Kwon,

Hyun Pyo Kim,

Myong Jo Kim,

Wanjoo Chun

Publication year - 2017

Publication title -

natural product sciences

Language(s) - English

Resource type - Journals

eISSN - 2288-9027

pISSN - 1226-3907

DOI - 10.20307/nps.2017.23.2.97

Subject(s) - scopoletin , bergapten , acetylcholinesterase , umbelliferone , chemistry , coumarin , psoralen , traditional medicine , stereochemistry , biology , botany , biochemistry , enzyme , medicine , dna , alternative medicine , pathology

Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin (5), geijerine (6), (−)-3'-acetyl hamaudol (7), 7-demethylsuberosine (8), dehydrogeijerin (9), (–)-hamaudol (10), (+)-visamminol (11), divaricatol (12), scopoletin (13), and decursidate (14), respectively. Among them, compounds 4 6, 8, 9, 13, and 14 were isolated for the first time from A. polymorpha. Dehydrogeijerin (6) and geijerin (9) were isolated for the first time from genus Angelica. All isolates tested for inhibitory activity against acetylcholinesterae. Compounds 1 to 13 showed acetylcholinesterase inhibitory activity with IC50 values ranging from 1.4 to 37.5 μM.

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