Optimization of Extraction Conditions for Active Compounds of Herbal Medicinal Formula, DF, by Response Surface Methodology | Zendy

Birang Jeong | Zendy; Seong Yeon Choi | Zendy; Hyeon Seok Jang | Zendy; Guijae Yoo | Zendy; SeungHyun Kim | Zendy; Jung Hwan Kim | Zendy; Yong Soo Kwon | Zendy; Jong Seong Roh | Zendy; Yoosik Yoon | Zendy; Soon Shik Shin | Zendy; Heejung Yang | Zendy

Open Access

Optimization of Extraction Conditions for Active Compounds of Herbal Medicinal Formula, DF, by Response Surface Methodology

Author(s) -

Birang Jeong,

Seong Yeon Choi,

Hyeon Seok Jang,

Guijae Yoo,

SeungHyun Kim,

Jung Hwan Kim,

Yong Soo Kwon,

Jong Seong Roh,

Yoosik Yoon,

Soon Shik Shin,

Heejung Yang

Publication year - 2017

Publication title -

natural product sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 25

eISSN - 2288-9027

pISSN - 1226-3907

DOI - 10.20307/nps.2017.23.1.9

Subject(s) - pseudoephedrine , ephedrine , extraction (chemistry) , response surface methodology , chromatography , traditional medicine , chemistry , box–behnken design , pharmacology , medicine

− DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in Korea. We tried to optimize the extraction conditions of two major components, (−)-ephedrine and (+)pseudoephedrine, in DF formula using response surface methodology with Box-Behnken design (BBD). The experimental conditions with 70% for EtOH concentrations, 4.8 hour for extraction hours and 8.7 times for the solvent to material ratio were suggested for the optimized extraction of DF formula with the highest amounts of (−)-ephedrine and (+)-pseudoephedrine in the designed model.

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