Anti-microbial and Anti-inflammatory Activity of New 4-methoxy-3-(methoxymethyl) Phenol and (E)-N′-(5-bromo-2-methoxybenzylidene)-4-methoxy Benzohydrazide Isolated fromCalotropis giganteanwhite | Zendy

Ramalingam Manivannan | Zendy; R. Shopna | Zendy

Open Access

Anti-microbial and Anti-inflammatory Activity of New 4-methoxy-3-(methoxymethyl) Phenol and (E)-N′-(5-bromo-2-methoxybenzylidene)-4-methoxy Benzohydrazide Isolated fromCalotropis giganteanwhite

Author(s) -

Ramalingam Manivannan,

R. Shopna

Publication year - 2017

Publication title -

natural product sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 25

eISSN - 2288-9027

pISSN - 1226-3907

DOI - 10.20307/nps.2017.23.1.69

Subject(s) - chemistry , antimicrobial , phenol , anti inflammatory , column chromatography , hydrazide , silica gel , chromatography , organic chemistry , phenols , proton nmr , nuclear chemistry , stereochemistry , pharmacology , biology

− A new phenol and hydrazide derivatives were obtained for the first time from the C. giganteawhite by silica gel column chromatography. The structure of the isolated compounds was identified by UV, IR NMR and MS. C. gigantea was scientifically reported for several medicinal properties viz. analgesic, antimicrobial and cytotoxic. In this screening work, anti-microbial activity of test compounds was found to be active against all organisms. Additionally, anti-inflammatory activity of the test groups has reduced the thickness of edema of the hind paw compared to the control group. Keywords−Calotropis gigantea white, anti-microbial activity, Anti-inflammatory activity, 4-methoxy-3-(methoxymethyl) phenol, (E)-N'-(5-bromo-2-methoxybenzylidene)-4-methoxy benzohydrazide

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